Pathology and Pathophysiology is an online open access journal dedicated to bridge the gap between research and clinical practice, providing valuable insights and advancements that improve understanding, diagnosis, and treatment of diseases.Pathology and Pathophysiology aims to advance the understanding of disease mechanisms and the pathological processes underlying various health conditions. Our goal is to provide a leading platform for high-quality research and scholarly discourse that enhances the knowledge of disease pathogenesis, diagnostic techniques, and therapeutic strategies, ultimately contributing to improved patient outcomes.We welcome original research articles, comprehensive reviews, case reports, and methodological papers that contribute to the advancement of knowledge in pathology and pathophysiology. The journal provide a forum for the exchange of ideas, foster interdisciplinary collaboration, and support the development of new approaches to understanding and treating diseases.

Disease Mechanisms: Research on the molecular, cellular, and tissue-level mechanisms that underlie various diseases, including genetic, environmental, and infectious factors.

Cellular and Molecular Pathology: Studies on the cellular and molecular changes associated with disease, including alterations in gene expression, protein function, and cellular signaling pathways.

Organ System Pathology: Investigations into the pathological processes affecting specific organ systems, such as cardiovascular, respiratory, gastrointestinal, and renal systems.

Histopathology: Articles on the microscopic examination of tissue samples, including the development of new staining techniques and imaging methods.

Tumor Biology and Oncology: Research on the mechanisms of tumor formation, progression, and metastasis, including studies on cancer biomarkers, molecular targets, and novel therapeutic approaches.

Pathophysiology: Studies on how diseases alter normal physiological processes and how these alterations contribute to the clinical manifestations of diseases.

Autoimmune and Inflammatory Diseases: Investigations into the pathogenesis of autoimmune and inflammatory conditions, including studies on immune system dysregulation and chronic inflammation.

Infectious Diseases: Research on the pathological effects of infectious agents, including bacteria, viruses, fungi, and parasites, and their impact on host tissues and systems.

Genetic and Rare Diseases: Studies on the pathophysiological mechanisms of genetic and rare diseases, including research on gene mutations, inheritance patterns, and potential therapeutic interventions.

Comparative Pathology: Research comparing disease processes across different species, including animal models, to gain insights into human pathology and develop new treatments.

Diagnostic Pathology: Advances in diagnostic techniques, including molecular diagnostics, imaging technologies, and biomarkers that enhance the accuracy and efficiency of disease diagnosis.

Clinical Pathology: Research on laboratory medicine, including the interpretation of laboratory test results, and their relevance to disease diagnosis and management.

Research

Benjamin Reardon*, Jennifer Hsu, Sandy Smith, Riana van der Linde, David A. Brown,  Elizabeth Tegg, and Sarah C. Sasson

The development of a high through-put flow cytometric assay for the identification of clonal T cells has proved challenging. We assessed the surface expression of a specific T Cell Receptor β-chain constant region using conjugated anti-JOV1.1 monoclonal antibodies to identify clonal T cell populations in a large diagnostic flow cytometry laboratory within a quaternary referral hospital. 37 cases were analysed.